Spautin-1
10mM in DMSO
- Product Code: 233768
CAS:
1262888-28-7
| Molecular Weight: | 271.27 g./mol | Molecular Formula: | C₁₅H₁₁F₂N₃ |
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| EC Number: | MDL Number: | MFCD16962292 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C, light-proof, inert gas |
Product Description:
Spautin-1 is primarily used in biomedical research for its ability to promote autophagy inhibition by targeting ubiquitin-specific peptidases USP10 and USP13. This action leads to the degradation of class III PI3K complexes, which are essential for autophagosome formation. Due to this mechanism, Spautin-1 is widely applied in cancer research, where modulating autophagy can sensitize tumor cells to chemotherapy or trigger cell death. It has also been investigated in neurodegenerative disease studies, as autophagy plays a key role in clearing misfolded proteins. Additionally, Spautin-1 serves as a tool compound in cellular biology to dissect autophagy-related signaling pathways and understand the role of deubiquitinating enzymes in cellular homeostasis.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | $313.52 |
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Spautin-1
Spautin-1 is primarily used in biomedical research for its ability to promote autophagy inhibition by targeting ubiquitin-specific peptidases USP10 and USP13. This action leads to the degradation of class III PI3K complexes, which are essential for autophagosome formation. Due to this mechanism, Spautin-1 is widely applied in cancer research, where modulating autophagy can sensitize tumor cells to chemotherapy or trigger cell death. It has also been investigated in neurodegenerative disease studies, as autophagy plays a key role in clearing misfolded proteins. Additionally, Spautin-1 serves as a tool compound in cellular biology to dissect autophagy-related signaling pathways and understand the role of deubiquitinating enzymes in cellular homeostasis.
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