SB 216763
10mM in DMSO
- Product Code: 233858
CAS:
280744-09-4
| Molecular Weight: | 371.22 g./mol | Molecular Formula: | C₁₉H₁₂Cl₂N₂O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD09753369 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
SB 216763 is widely used in biomedical research as a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3). It is commonly applied in studies related to cellular signaling pathways, particularly the Wnt/β-catenin pathway, where it helps stabilize β-catenin by preventing its phosphorylation and degradation. This property makes it valuable in research on cell proliferation, differentiation, and tissue regeneration.
It is frequently used in stem cell research to promote the maintenance of pluripotency and to direct differentiation, especially toward mesodermal and cardiac lineages. SB 216763 also supports neuronal survival in models of neurodegenerative diseases, making it a tool compound in studies of Alzheimer's, Parkinson’s, and other conditions involving GSK-3 dysregulation.
Additionally, it has been used in cancer research to investigate the role of GSK-3 in tumor progression, as GSK-3 can act as both a tumor suppressor and promoter depending on context. Its ability to modulate inflammation and apoptosis further extends its application in models of ischemia, injury, and immune response.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿5,210.00 |
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SB 216763
SB 216763 is widely used in biomedical research as a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3). It is commonly applied in studies related to cellular signaling pathways, particularly the Wnt/β-catenin pathway, where it helps stabilize β-catenin by preventing its phosphorylation and degradation. This property makes it valuable in research on cell proliferation, differentiation, and tissue regeneration.
It is frequently used in stem cell research to promote the maintenance of pluripotency and to direct differentiation, especially toward mesodermal and cardiac lineages. SB 216763 also supports neuronal survival in models of neurodegenerative diseases, making it a tool compound in studies of Alzheimer's, Parkinson’s, and other conditions involving GSK-3 dysregulation.
Additionally, it has been used in cancer research to investigate the role of GSK-3 in tumor progression, as GSK-3 can act as both a tumor suppressor and promoter depending on context. Its ability to modulate inflammation and apoptosis further extends its application in models of ischemia, injury, and immune response.
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