SC-514
10mM in DMSO
- Product Code: 233931
CAS:
354812-17-2
| Molecular Weight: | 224.30 g./mol | Molecular Formula: | C₉H₈N₂OS₂ |
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| Density: | Storage Condition: | -20°C |
Product Description:
SC-514 is primarily used in research settings as a selective inhibitor of IkappaB kinase-2 (IKK-2), a key enzyme involved in the activation of the NF-κB signaling pathway. This pathway plays a central role in regulating the expression of genes associated with inflammation, immune responses, and cell survival. By inhibiting IKK-2, SC-514 helps suppress the activation of NF-κB, making it a valuable tool for studying inflammatory processes and potential therapeutic targets.
It is commonly applied in cellular and molecular studies to investigate the role of NF-κB in diseases such as rheumatoid arthritis, inflammatory bowel disease, and other chronic inflammatory conditions. Researchers use SC-514 to dissect signaling pathways and evaluate the downstream effects of IKK-2 inhibition, including reduced production of pro-inflammatory cytokines like TNF-α and IL-6.
Due to its specificity, SC-514 supports the development and validation of anti-inflammatory drugs, although it is not used clinically. Its application remains confined to laboratory research, particularly in pharmacology and immunology, where understanding the mechanics of inflammation is critical.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿3,350.00 |
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SC-514
SC-514 is primarily used in research settings as a selective inhibitor of IkappaB kinase-2 (IKK-2), a key enzyme involved in the activation of the NF-κB signaling pathway. This pathway plays a central role in regulating the expression of genes associated with inflammation, immune responses, and cell survival. By inhibiting IKK-2, SC-514 helps suppress the activation of NF-κB, making it a valuable tool for studying inflammatory processes and potential therapeutic targets.
It is commonly applied in cellular and molecular studies to investigate the role of NF-κB in diseases such as rheumatoid arthritis, inflammatory bowel disease, and other chronic inflammatory conditions. Researchers use SC-514 to dissect signaling pathways and evaluate the downstream effects of IKK-2 inhibition, including reduced production of pro-inflammatory cytokines like TNF-α and IL-6.
Due to its specificity, SC-514 supports the development and validation of anti-inflammatory drugs, although it is not used clinically. Its application remains confined to laboratory research, particularly in pharmacology and immunology, where understanding the mechanics of inflammation is critical.
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