SB415286
10mM in DMSO
- Product Code: 234063
CAS:
264218-23-7
| Molecular Weight: | 359.72 g./mol | Molecular Formula: | C₁₆H₁₀ClN₃O₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD04039789 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
SB415286 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple signaling pathways including Wnt, insulin, and neurodevelopmental pathways. It is widely used in research to modulate GSK-3 activity, making it a valuable tool in studies related to neurodegenerative diseases such as Alzheimer's, where GSK-3 overactivity is linked to tau protein hyperphosphorylation.
In cancer research, SB415286 has been applied to investigate the role of GSK-3 in cell proliferation and apoptosis. By inhibiting GSK-3, it can stabilize β-catenin, thereby activating Wnt signaling, which helps in studying stem cell maintenance, differentiation, and tumorigenesis.
It is also used in cellular reprogramming and regenerative medicine studies, where modulation of GSK-3 enhances the efficiency of induced pluripotent stem cell generation. Due to its ability to cross cell membranes effectively, SB415286 is favored in cell-based assays requiring intracellular enzyme inhibition.
Its application extends to diabetes research, where GSK-3 inhibition improves insulin signaling and glucose uptake in cellular models, offering insights into potential therapeutic strategies for insulin resistance.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿7,830.00 |
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SB415286
SB415286 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3), an enzyme involved in multiple signaling pathways including Wnt, insulin, and neurodevelopmental pathways. It is widely used in research to modulate GSK-3 activity, making it a valuable tool in studies related to neurodegenerative diseases such as Alzheimer's, where GSK-3 overactivity is linked to tau protein hyperphosphorylation.
In cancer research, SB415286 has been applied to investigate the role of GSK-3 in cell proliferation and apoptosis. By inhibiting GSK-3, it can stabilize β-catenin, thereby activating Wnt signaling, which helps in studying stem cell maintenance, differentiation, and tumorigenesis.
It is also used in cellular reprogramming and regenerative medicine studies, where modulation of GSK-3 enhances the efficiency of induced pluripotent stem cell generation. Due to its ability to cross cell membranes effectively, SB415286 is favored in cell-based assays requiring intracellular enzyme inhibition.
Its application extends to diabetes research, where GSK-3 inhibition improves insulin signaling and glucose uptake in cellular models, offering insights into potential therapeutic strategies for insulin resistance.
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