(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4,4-trifluorobutanoic acid
97%
- Product Code: 235112
CAS:
181128-48-3
| Molecular Weight: | 379.33 g./mol | Molecular Formula: | C₁₉H₁₆F₃NO₄ |
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| Density: | Storage Condition: | 2-8°C |
Product Description:
Widely used in peptide synthesis, this compound serves as a protected chiral amino acid building block, particularly effective in introducing trifluoromethyl-modified residues into peptide chains. The Fmoc group allows for mild base-labile protection, compatible with solid-phase peptide synthesis (SPPS), enabling the stepwise assembly of complex peptides. Its stereochemistry ensures control over chirality, which is critical for biological activity in pharmaceutical applications. The electron-withdrawing trifluoromethyl group enhances metabolic stability and lipophilicity of the resulting peptides, making it valuable in the development of peptidomimetics and bioactive molecules with improved pharmacokinetic profiles. Commonly employed in medicinal chemistry for designing enzyme inhibitors or receptor ligands where fluorination modulates binding affinity and resistance to degradation.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿4,820.00 |
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| 250mg | 10-20 days | ฿9,620.00 |
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| 5g | 10-20 days | ฿144,290.00 |
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| 1g | 10-20 days | ฿38,450.00 |
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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4,4-trifluorobutanoic acid
Widely used in peptide synthesis, this compound serves as a protected chiral amino acid building block, particularly effective in introducing trifluoromethyl-modified residues into peptide chains. The Fmoc group allows for mild base-labile protection, compatible with solid-phase peptide synthesis (SPPS), enabling the stepwise assembly of complex peptides. Its stereochemistry ensures control over chirality, which is critical for biological activity in pharmaceutical applications. The electron-withdrawing trifluoromethyl group enhances metabolic stability and lipophilicity of the resulting peptides, making it valuable in the development of peptidomimetics and bioactive molecules with improved pharmacokinetic profiles. Commonly employed in medicinal chemistry for designing enzyme inhibitors or receptor ligands where fluorination modulates binding affinity and resistance to degradation.
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