(2S,4S)-Fmoc-4-trifluoromethylpyrrolidine-2-carboxylic acid
98%
- Product Code: 237315
CAS:
1242934-32-2
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| Density: | Storage Condition: | Room temperature |
Product Description:
Widely used in peptide synthesis, this compound serves as a chiral building block for the preparation of structurally constrained peptides. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in the design of bioactive peptides with improved pharmacokinetic properties. It is especially useful in medicinal chemistry for developing enzyme inhibitors or receptor modulators where stereochemistry and conformational rigidity play critical roles. The Fmoc group allows for solid-phase peptide synthesis using standard Fmoc/tBu strategies, enabling efficient incorporation into peptide chains under mild basic conditions. Its rigid pyrrolidine scaffold is often employed to induce specific turns or folds in peptide backbones, influencing secondary structure and target selectivity.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | $238.81 |
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| 250mg | 10-20 days | $508.62 |
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| 1g | 10-20 days | $1,673.68 |
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(2S,4S)-Fmoc-4-trifluoromethylpyrrolidine-2-carboxylic acid
Widely used in peptide synthesis, this compound serves as a chiral building block for the preparation of structurally constrained peptides. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in the design of bioactive peptides with improved pharmacokinetic properties. It is especially useful in medicinal chemistry for developing enzyme inhibitors or receptor modulators where stereochemistry and conformational rigidity play critical roles. The Fmoc group allows for solid-phase peptide synthesis using standard Fmoc/tBu strategies, enabling efficient incorporation into peptide chains under mild basic conditions. Its rigid pyrrolidine scaffold is often employed to induce specific turns or folds in peptide backbones, influencing secondary structure and target selectivity.
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