(S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate
95%
- Product Code: 237978
CAS:
215918-21-1
| Molecular Weight: | 237.24 g./mol | Molecular Formula: | C₁₀H₁₇F₂NO₃ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD12755205 | |
| Melting Point: | Boiling Point: | 293.4±40.0 °C(Predicted) | |
| Density: | 1.21±0.1 g/cm3(Predicted) | Storage Condition: | 2-8°C, sealed, dry |
Product Description:
Used as a key chiral intermediate in the synthesis of pharmaceutical agents, particularly in the development of fluorinated analogs of bioactive molecules. Its structure supports conformational rigidity and enhanced metabolic stability, making it valuable in medicinal chemistry for optimizing drug candidates. Commonly employed in the preparation of protease inhibitors and central nervous system-targeted compounds due to its ability to improve blood-brain barrier penetration. The presence of the hydroxymethyl group allows for further functionalization, enabling linkage to other pharmacophores or prodrug modifications. Widely utilized in asymmetric synthesis routes where stereochemical control is critical for biological activity.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 250mg | 10-20 days | $252.42 |
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| 1g | 10-20 days | $680.59 |
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| 5g | 10-20 days | $2,499.87 |
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(S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate
Used as a key chiral intermediate in the synthesis of pharmaceutical agents, particularly in the development of fluorinated analogs of bioactive molecules. Its structure supports conformational rigidity and enhanced metabolic stability, making it valuable in medicinal chemistry for optimizing drug candidates. Commonly employed in the preparation of protease inhibitors and central nervous system-targeted compounds due to its ability to improve blood-brain barrier penetration. The presence of the hydroxymethyl group allows for further functionalization, enabling linkage to other pharmacophores or prodrug modifications. Widely utilized in asymmetric synthesis routes where stereochemical control is critical for biological activity.
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