3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole
95%
- Product Code: 238405
CAS:
2915301-91-4
| Molecular Weight: | 276.06 g./mol | Molecular Formula: | C₁₁H₁₆BF₃N₂O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD24540322 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C, Inert Gas |
Product Description:
Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key boronic ester reagent for constructing carbon-carbon bonds in pharmaceutical and agrochemical synthesis. Its pyrazole core is a common pharmacophore, making it valuable for developing bioactive molecules. The trifluoroethyl group enhances metabolic stability and lipophilicity, which is beneficial in drug design. It is particularly useful in the preparation of kinase inhibitors and other medicinal agents where fluorinated heterocycles improve potency and pharmacokinetic properties. The boronate ester functionality allows for mild, palladium-catalyzed coupling with aryl or heteroaryl halides, enabling efficient library synthesis in medicinal chemistry campaigns.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | Ft106,974.20 |
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| 0.250 | 10-20 days | Ft171,179.73 |
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| 1.000 | 10-20 days | Ft445,025.28 |
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3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole
Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key boronic ester reagent for constructing carbon-carbon bonds in pharmaceutical and agrochemical synthesis. Its pyrazole core is a common pharmacophore, making it valuable for developing bioactive molecules. The trifluoroethyl group enhances metabolic stability and lipophilicity, which is beneficial in drug design. It is particularly useful in the preparation of kinase inhibitors and other medicinal agents where fluorinated heterocycles improve potency and pharmacokinetic properties. The boronate ester functionality allows for mild, palladium-catalyzed coupling with aryl or heteroaryl halides, enabling efficient library synthesis in medicinal chemistry campaigns.
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