trans-2-(2,4-difluorophenyl)cyclopropane-1-carboxylic acid
91%
- Product Code: 241828
CAS:
1391625-51-6
| Molecular Weight: | 198.17 g./mol | Molecular Formula: | C₁₀H₈F₂O₂ |
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| Density: | Storage Condition: | 2-8℃ |
Product Description:
Used as a key chiral intermediate in the synthesis of antifungal agents, particularly in the production of triazole antifungals like fluconazole and related derivatives. Its cyclopropane structure with specific stereochemistry enhances binding affinity to fungal cytochrome P450 enzymes, improving selectivity and potency. The difluorophenyl group contributes to metabolic stability and lipophilicity, which aids in tissue penetration and oral bioavailability. Commonly employed in pharmaceutical research and development for optimizing antifungal drug candidates.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿3,025.00 |
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| 250mg | 10-20 days | ฿9,250.00 |
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| 1g | 10-20 days | ฿24,990.00 |
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trans-2-(2,4-difluorophenyl)cyclopropane-1-carboxylic acid
Used as a key chiral intermediate in the synthesis of antifungal agents, particularly in the production of triazole antifungals like fluconazole and related derivatives. Its cyclopropane structure with specific stereochemistry enhances binding affinity to fungal cytochrome P450 enzymes, improving selectivity and potency. The difluorophenyl group contributes to metabolic stability and lipophilicity, which aids in tissue penetration and oral bioavailability. Commonly employed in pharmaceutical research and development for optimizing antifungal drug candidates.
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