5-[2-(Trifluoromethoxy)phenyl]-2H-tetrazole
95%
- Product Code: 242585
CAS:
1261268-92-1
| Molecular Weight: | 230.15 g./mol | Molecular Formula: | C₈H₅F₃N₄O |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD18375292 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C |
Product Description:
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the preparation of sartan-class antihypertensive drugs such as telmisartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres due to its metabolic stability and improved lipophilicity. Additionally, it finds use in agrochemical research for designing novel active ingredients with enhanced activity and environmental stability.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1g | 10-20 days | ฿4,081.00 |
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| 25g | 10-20 days | ฿42,251.00 |
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| 5g | 10-20 days | ฿12,870.00 |
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5-[2-(Trifluoromethoxy)phenyl]-2H-tetrazole
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the preparation of sartan-class antihypertensive drugs such as telmisartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres due to its metabolic stability and improved lipophilicity. Additionally, it finds use in agrochemical research for designing novel active ingredients with enhanced activity and environmental stability.
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