5-(3-(Trifluoromethyl)Phenyl)-1H-Tetrazole
97%
- Product Code: 243936
CAS:
92712-48-6
| Molecular Weight: | 214.15 g./mol | Molecular Formula: | C₈H₅F₃N₄ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00068098 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C |
Product Description:
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and losartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor. Due to its metabolic stability and improved pharmacokinetic profile, it plays a crucial role in increasing the potency and oral bioavailability of these medications. Also employed in agrochemicals and coordination chemistry as a ligand for metal ions.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 100mg | 10-20 days | ฿1,510.00 |
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5-(3-(Trifluoromethyl)Phenyl)-1H-Tetrazole
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and losartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor. Due to its metabolic stability and improved pharmacokinetic profile, it plays a crucial role in increasing the potency and oral bioavailability of these medications. Also employed in agrochemicals and coordination chemistry as a ligand for metal ions.
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