UMI-77
10mM in DMSO
- Product Code: 244967
CAS:
518303-20-3
| Molecular Weight: | 468.34 g./mol | Molecular Formula: | C₁₈H₁₄BrNO₅S₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD03471890 | |
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| Density: | Storage Condition: | -20°C |
Product Description:
UMI-77 is a small molecule inhibitor that selectively targets the Bcl-2 family protein Mcl-1 (Myeloid cell leukemia 1). Its primary application lies in cancer research, particularly in studies focused on overcoming apoptosis resistance in tumor cells. Mcl-1 is often overexpressed in various cancers, including leukemia, lymphoma, and solid tumors, where it promotes cell survival by inhibiting programmed cell death. UMI-77 binds to the hydrophobic groove of Mcl-1, disrupting its interaction with pro-apoptotic proteins like Bak and Bax, thereby restoring the cell’s ability to undergo apoptosis.
Due to its specificity, UMI-77 is widely used as a research tool to probe Mcl-1-dependent survival pathways and to evaluate the therapeutic potential of Mcl-1 inhibition. It has shown cytotoxic effects in Mcl-1-dependent cancer cell lines and is often tested in combination with other chemotherapeutic agents to enhance tumor cell killing. While still in the preclinical stage, UMI-77 serves as a valuable lead compound for developing targeted therapies against cancers reliant on Mcl-1 for survival.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | $275.58 |
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UMI-77
UMI-77 is a small molecule inhibitor that selectively targets the Bcl-2 family protein Mcl-1 (Myeloid cell leukemia 1). Its primary application lies in cancer research, particularly in studies focused on overcoming apoptosis resistance in tumor cells. Mcl-1 is often overexpressed in various cancers, including leukemia, lymphoma, and solid tumors, where it promotes cell survival by inhibiting programmed cell death. UMI-77 binds to the hydrophobic groove of Mcl-1, disrupting its interaction with pro-apoptotic proteins like Bak and Bax, thereby restoring the cell’s ability to undergo apoptosis.
Due to its specificity, UMI-77 is widely used as a research tool to probe Mcl-1-dependent survival pathways and to evaluate the therapeutic potential of Mcl-1 inhibition. It has shown cytotoxic effects in Mcl-1-dependent cancer cell lines and is often tested in combination with other chemotherapeutic agents to enhance tumor cell killing. While still in the preclinical stage, UMI-77 serves as a valuable lead compound for developing targeted therapies against cancers reliant on Mcl-1 for survival.
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