V-9302
10mM in DMSO
- Product Code: 245209
CAS:
1855871-76-9
| Molecular Weight: | 538.680 g./mol | Molecular Formula: | C₃₄H₃₈N₂O₄ |
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| Density: | Storage Condition: | -20°C |
Product Description:
V-9302 is a selective inhibitor of the monocarboxylate transporter 1 (MCT1), making it a valuable tool in cancer research, particularly in studies involving tumor metabolism. Cancer cells often rely on glycolysis for energy production, leading to high lactate generation. MCT1 plays a key role in transporting lactate out of these cells, helping maintain a favorable intracellular pH and supporting continued glycolytic activity. By blocking MCT1, V-9302 disrupts lactate efflux, causing intracellular acidification and impairing cancer cell growth and survival.
This compound has shown activity in preclinical models against cancers with high glycolytic rates, such as lymphoma, leukemia, and certain solid tumors. It is often used in combination with other metabolic inhibitors or chemotherapeutic agents to exploit metabolic vulnerabilities in cancer cells. Additionally, V-9302 helps researchers study the role of MCT1 in immune cell function and tumor microenvironment interactions, offering insights into potential therapeutic strategies targeting cancer metabolism.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 1ml | 10-20 days | ฿22,290.00 |
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V-9302
V-9302 is a selective inhibitor of the monocarboxylate transporter 1 (MCT1), making it a valuable tool in cancer research, particularly in studies involving tumor metabolism. Cancer cells often rely on glycolysis for energy production, leading to high lactate generation. MCT1 plays a key role in transporting lactate out of these cells, helping maintain a favorable intracellular pH and supporting continued glycolytic activity. By blocking MCT1, V-9302 disrupts lactate efflux, causing intracellular acidification and impairing cancer cell growth and survival.
This compound has shown activity in preclinical models against cancers with high glycolytic rates, such as lymphoma, leukemia, and certain solid tumors. It is often used in combination with other metabolic inhibitors or chemotherapeutic agents to exploit metabolic vulnerabilities in cancer cells. Additionally, V-9302 helps researchers study the role of MCT1 in immune cell function and tumor microenvironment interactions, offering insights into potential therapeutic strategies targeting cancer metabolism.
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