huMERTK-CHO-S,

huMERTK-CHO-S is a recombinant human protein expressed in Chinese Hamster Ovary (CHO) cells, featuring a specific post-translational modification pattern due to the host system. It is primarily used in immunological and oncology research to study the role of the MERTK receptor in immune regulation and cancer progression. The protein serves as a critical tool for investigating MERTK-mediated signaling pathways, particularly in macrophages and dendritic cells, where it contributes to the suppression of immune responses and the promotion of tissue homeostasis. Its application extends to drug development, where it is used as a target antigen for screening and characterizing monoclonal antibodies or small molecule inhibitors aimed at blocking MERTK activity in tumor microenvironments. Due to its role in enabling cancer immune evasion, huMERTK-CHO-S is instrumental in immuno-oncology assays, including binding affinity studies, neutralization assays, and pharmacokinetic evaluations of therapeutic candidates. Additionally, it supports the development of diagnostic tools for cancers and autoimmune diseases linked to MERTK dysregulation.

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