N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine
97%
- Product Code: 43847
CAS:
81256-89-5
| Molecular Weight: | 769.96 g./mol | Molecular Formula: | C₄₁H₅₁N₅O₈Si |
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| Density: | 1.25±0.1 g/cm3(Predicted) | Storage Condition: | 2-8°C |
Product Description:
This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of nucleic acid research. It serves as a protected guanosine derivative, where the isobutyryl group protects the exocyclic amine, the 4,4'-dimethoxytrityl (DMT) group protects the 5'-hydroxyl, and the tert-butyldimethylsilyl (TBDMS) group protects the 3'-hydroxyl. These protective groups are crucial during solid-phase oligonucleotide synthesis, as they prevent unwanted side reactions and allow for sequential addition of nucleotide units. The DMT group can be selectively removed under mild acidic conditions, enabling stepwise elongation of the oligonucleotide chain. This compound is particularly valuable in the production of modified RNA or DNA sequences for applications such as gene editing, antisense therapy, and molecular diagnostics. Its use ensures high efficiency and precision in the synthesis of complex nucleic acid molecules.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 | 10-20 days | ฿16,101.00 |
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N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine
This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of nucleic acid research. It serves as a protected guanosine derivative, where the isobutyryl group protects the exocyclic amine, the 4,4'-dimethoxytrityl (DMT) group protects the 5'-hydroxyl, and the tert-butyldimethylsilyl (TBDMS) group protects the 3'-hydroxyl. These protective groups are crucial during solid-phase oligonucleotide synthesis, as they prevent unwanted side reactions and allow for sequential addition of nucleotide units. The DMT group can be selectively removed under mild acidic conditions, enabling stepwise elongation of the oligonucleotide chain. This compound is particularly valuable in the production of modified RNA or DNA sequences for applications such as gene editing, antisense therapy, and molecular diagnostics. Its use ensures high efficiency and precision in the synthesis of complex nucleic acid molecules.
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