3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 2'-CE phosphoramidite
95%
- Product Code: 43849
CAS:
1445905-51-0
| Molecular Weight: | 970.18 g./mol | Molecular Formula: | C₅₀H₆₈N₇O₉PSi |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD30475539 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8°C, dry and sealed |
Product Description:
This compound is primarily used in the synthesis of oligonucleotides, particularly in the field of molecular biology and genetic research. It serves as a key building block in solid-phase oligonucleotide synthesis, enabling the precise assembly of DNA or RNA sequences. The tert-butyldimethylsilyl (TBDMS) group protects the 3'-hydroxyl, while the dimethoxytrityl (DMT) group protects the 5'-hydroxyl, ensuring controlled and selective coupling during the synthesis process. The isobutyryl group on the guanosine base provides additional protection, preventing unwanted side reactions. This phosphoramidite is essential for creating custom oligonucleotides for applications such as PCR primers, gene editing, and synthetic biology. Its stability and reactivity make it a critical reagent in high-throughput DNA synthesis platforms.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | ฿2,500.00 |
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| 0.250 | 10-20 days | ฿4,250.00 |
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| 1.000 | 10-20 days | ฿11,270.00 |
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| 5.000 | 10-20 days | ฿52,620.00 |
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3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 2'-CE phosphoramidite
This compound is primarily used in the synthesis of oligonucleotides, particularly in the field of molecular biology and genetic research. It serves as a key building block in solid-phase oligonucleotide synthesis, enabling the precise assembly of DNA or RNA sequences. The tert-butyldimethylsilyl (TBDMS) group protects the 3'-hydroxyl, while the dimethoxytrityl (DMT) group protects the 5'-hydroxyl, ensuring controlled and selective coupling during the synthesis process. The isobutyryl group on the guanosine base provides additional protection, preventing unwanted side reactions. This phosphoramidite is essential for creating custom oligonucleotides for applications such as PCR primers, gene editing, and synthetic biology. Its stability and reactivity make it a critical reagent in high-throughput DNA synthesis platforms.
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