5'-O-DMT-N6-iBu-dA
97%
- Product Code: 47937
CAS:
190834-10-7
| Molecular Weight: | 623.71 g./mol | Molecular Formula: | C₃₅H₃₇N₅O₆ |
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| Density: | Storage Condition: | 2-8℃ |
Product Description:
This chemical is primarily used in the field of oligonucleotide synthesis, particularly in the production of modified DNA strands. It serves as a protected nucleoside monomer, where the 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, and the N6 position of the adenine base is modified with an isobutyl group. This protection strategy allows for controlled and sequential addition of nucleotides during solid-phase synthesis, ensuring high precision in the construction of custom DNA sequences. It is especially valuable in the development of therapeutic oligonucleotides, such as antisense molecules, siRNAs, and aptamers, which are used in gene silencing, targeted therapy, and diagnostic applications. The modifications enhance the stability and specificity of the synthesized oligonucleotides, making them more effective in biological systems.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.010 | 10-20 days | £93.23 |
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| 0.050 | 10-20 days | £325.68 |
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5'-O-DMT-N6-iBu-dA
This chemical is primarily used in the field of oligonucleotide synthesis, particularly in the production of modified DNA strands. It serves as a protected nucleoside monomer, where the 5'-hydroxyl group is protected by a dimethoxytrityl (DMT) group, and the N6 position of the adenine base is modified with an isobutyl group. This protection strategy allows for controlled and sequential addition of nucleotides during solid-phase synthesis, ensuring high precision in the construction of custom DNA sequences. It is especially valuable in the development of therapeutic oligonucleotides, such as antisense molecules, siRNAs, and aptamers, which are used in gene silencing, targeted therapy, and diagnostic applications. The modifications enhance the stability and specificity of the synthesized oligonucleotides, making them more effective in biological systems.
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