Fmoc-Val-Cit-PAB-MMAE
≥98%
- Product Code: 60235
CAS:
1350456-56-2
| Molecular Weight: | 1345.67 g./mol | Molecular Formula: | C₇₃H₁₀₄N₁₀O₁₄ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | 2-8℃ |
Product Description:
This compound is primarily used in the development of antibody-drug conjugates (ADCs), which are targeted cancer therapies. It serves as a linker-payload component, connecting a cytotoxic drug (MMAE) to a monoclonal antibody. The Fmoc group protects the valine residue during synthesis, while the Val-Cit dipeptide sequence is cleavable by cathepsin B, an enzyme overexpressed in cancer cells. The PAB spacer ensures efficient release of the cytotoxic agent upon cleavage. Once the ADC binds to cancer cell surface antigens and is internalized, the linker is cleaved, releasing MMAE to induce apoptosis in tumor cells. This approach enhances the specificity and reduces the systemic toxicity of chemotherapy.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | White to Off-white to Yellow Solid |
| PURITY | 97.5-100 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | ฿35,000.00 |
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| 0.005 | 10-20 days | ฿79,800.00 |
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Fmoc-Val-Cit-PAB-MMAE
This compound is primarily used in the development of antibody-drug conjugates (ADCs), which are targeted cancer therapies. It serves as a linker-payload component, connecting a cytotoxic drug (MMAE) to a monoclonal antibody. The Fmoc group protects the valine residue during synthesis, while the Val-Cit dipeptide sequence is cleavable by cathepsin B, an enzyme overexpressed in cancer cells. The PAB spacer ensures efficient release of the cytotoxic agent upon cleavage. Once the ADC binds to cancer cell surface antigens and is internalized, the linker is cleaved, releasing MMAE to induce apoptosis in tumor cells. This approach enhances the specificity and reduces the systemic toxicity of chemotherapy.
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| Stable in pH range | - |
| Solubility | - |
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| INCI | - |
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