ONT-093 (OC 144093)

≥98%

  • Product Code: 62527
  CAS:    216227-54-2
Molecular Weight: 494.7 g./mol Molecular Formula: C₃₂H₃₈N₄O
EC Number: MDL Number:
Melting Point: Boiling Point:
Density: Storage Condition: -20°C, airtight, dry
Product Description: ONT-093, also known as OC 144093, is primarily recognized for its role as a potent inhibitor of P-glycoprotein (P-gp), a protein that plays a significant role in multidrug resistance (MDR) in cancer cells. By inhibiting P-gp, ONT-093 enhances the intracellular accumulation of chemotherapeutic agents, thereby increasing their efficacy in treating drug-resistant cancers. This makes it a valuable adjunct in combination therapies, particularly for cancers that have developed resistance to standard treatments. In addition to its application in oncology, ONT-093 has been explored for its potential to improve the bioavailability of various drugs that are substrates of P-gp. This includes enhancing the absorption and distribution of drugs across the blood-brain barrier, which can be particularly beneficial for treating neurological disorders where drug delivery is often a challenge. Research has also indicated that ONT-093 may have utility in reversing multidrug resistance in infectious diseases, particularly in cases where pathogens have developed resistance to antimicrobial agents. By inhibiting efflux pumps similar to P-gp in bacteria, ONT-093 can potentially restore the effectiveness of antibiotics that have become less potent due to resistance mechanisms. Overall, ONT-093's ability to modulate drug transport mechanisms makes it a promising candidate for improving therapeutic outcomes in various fields, including cancer treatment, neurology, and infectious disease management.
Sizes / Availability / Pricing:
Size (g) Availability Price Quantity
0.005 10-20 days ฿71,865.00
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ONT-093 (OC 144093)
ONT-093, also known as OC 144093, is primarily recognized for its role as a potent inhibitor of P-glycoprotein (P-gp), a protein that plays a significant role in multidrug resistance (MDR) in cancer cells. By inhibiting P-gp, ONT-093 enhances the intracellular accumulation of chemotherapeutic agents, thereby increasing their efficacy in treating drug-resistant cancers. This makes it a valuable adjunct in combination therapies, particularly for cancers that have developed resistance to standard treatments. In addition to its application in oncology, ONT-093 has been explored for its potential to improve the bioavailability of various drugs that are substrates of P-gp. This includes enhancing the absorption and distribution of drugs across the blood-brain barrier, which can be particularly beneficial for treating neurological disorders where drug delivery is often a challenge. Research has also indicated that ONT-093 may have utility in reversing multidrug resistance in infectious diseases, particularly in cases where pathogens have developed resistance to antimicrobial agents. By inhibiting efflux pumps similar to P-gp in bacteria, ONT-093 can potentially restore the effectiveness of antibiotics that have become less potent due to resistance mechanisms. Overall, ONT-093's ability to modulate drug transport mechanisms makes it a promising candidate for improving therapeutic outcomes in various fields, including cancer treatment, neurology, and infectious disease management.
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