5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
95%
- Product Code: 64565
CAS:
26166-92-7
| Molecular Weight: | 337.13 g./mol | Molecular Formula: | C₁₃H₉BrN₂O₄ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | >230 °C | Boiling Point: | 564.3±45.0 °C(Predicted) |
| Density: | 1.794±0.06 g/cm3(Predicted) | Storage Condition: | 2-8℃ |
Product Description:
This compound is primarily utilized in the field of medicinal chemistry, particularly in the development of targeted therapies for cancer. It functions as a key intermediate in the synthesis of small molecule inhibitors that modulate protein-protein interactions, specifically those involved in the ubiquitin-proteasome pathway. By disrupting this pathway, it aids in the degradation of oncogenic proteins, making it a valuable component in the design of drugs for treating hematologic malignancies such as multiple myeloma. Additionally, its structure is leveraged in the creation of immunomodulatory drugs (IMiDs), which enhance the immune system's ability to target and destroy cancerous cells. Its role in these applications underscores its significance in advancing cancer treatment strategies.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | Off white solid |
| PURITY | 94.5-100 |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | £9.05 |
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| 1.000 | 10-20 days | £43.42 |
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| 5.000 | 10-20 days | £199.48 |
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| 25.000 | 10-20 days | £893.37 |
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5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
This compound is primarily utilized in the field of medicinal chemistry, particularly in the development of targeted therapies for cancer. It functions as a key intermediate in the synthesis of small molecule inhibitors that modulate protein-protein interactions, specifically those involved in the ubiquitin-proteasome pathway. By disrupting this pathway, it aids in the degradation of oncogenic proteins, making it a valuable component in the design of drugs for treating hematologic malignancies such as multiple myeloma. Additionally, its structure is leveraged in the creation of immunomodulatory drugs (IMiDs), which enhance the immune system's ability to target and destroy cancerous cells. Its role in these applications underscores its significance in advancing cancer treatment strategies.
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