DS-437
≥98% (HPLC)
- Product Code: 71197
CAS:
1674364-87-4
| Molecular Weight: | 397.45 g./mol | Molecular Formula: | C₁₅H₂₃N₇O₄S |
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| Density: | Storage Condition: | 2-8°C |
Product Description:
DS-437 is primarily utilized in research settings as a potent and selective inhibitor of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). This enzyme plays a crucial role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme involved in various cellular processes, including energy metabolism and DNA repair. By inhibiting NAMPT, DS-437 is used to study the effects of NAD+ depletion in cells, which can lead to insights into cancer biology, as many cancer cells rely heavily on NAD+ for their rapid proliferation. Additionally, DS-437 serves as a valuable tool in pharmacological studies aimed at developing new therapeutic strategies for cancer treatment by targeting NAD+ metabolism. Its application extends to exploring the potential of NAMPT inhibition in other diseases where NAD+ dysregulation is implicated, such as neurodegenerative disorders and metabolic syndromes.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | ฿4,914.00 |
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DS-437
DS-437 is primarily utilized in research settings as a potent and selective inhibitor of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). This enzyme plays a crucial role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a vital coenzyme involved in various cellular processes, including energy metabolism and DNA repair. By inhibiting NAMPT, DS-437 is used to study the effects of NAD+ depletion in cells, which can lead to insights into cancer biology, as many cancer cells rely heavily on NAD+ for their rapid proliferation. Additionally, DS-437 serves as a valuable tool in pharmacological studies aimed at developing new therapeutic strategies for cancer treatment by targeting NAD+ metabolism. Its application extends to exploring the potential of NAMPT inhibition in other diseases where NAD+ dysregulation is implicated, such as neurodegenerative disorders and metabolic syndromes.
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