4-(Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester
98%
- Product Code: 77221
Alias:
SMCC
CAS:
64987-85-5
Properties:
Chloroform: soluble 50 mg/mL DMF: soluble
| Molecular Weight: | 334.33 g./mol | Molecular Formula: | C₁₆H₁₈N₂O₆ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00009634 | |
| Melting Point: | 180-182 °C(lit.) | Boiling Point: | |
| Density: | Storage Condition: | -20℃ |
Product Description:
This compound is widely used in bioconjugation and protein labeling applications. Its maleimide group reacts selectively with thiol groups (-SH) in cysteine residues of proteins, enabling the attachment of biomolecules. The N-hydroxysuccinimide (NHS) ester moiety allows it to react with primary amines (-NH2) present in lysine residues or other amine-containing molecules, facilitating crosslinking or labeling. It is particularly useful in antibody-drug conjugates (ADCs), where it links antibodies to cytotoxic drugs, enhancing targeted cancer therapy. Additionally, it is employed in the preparation of biosensors, immobilization of enzymes, and the study of protein interactions. Its bifunctional nature makes it a versatile tool in biochemical research and therapeutic development.
Product Specification:
| Test | Specification |
|---|---|
| Purity | 97.5 100% |
| APPEARANCE | White to off-white powder |
| INFRARED SPECTRUM | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.200 | 10-20 days | ฿1,370.00 |
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| 1.000 | 10-20 days | ฿5,200.00 |
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| 5.000 | 10-20 days | ฿14,680.00 |
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4-(Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester
This compound is widely used in bioconjugation and protein labeling applications. Its maleimide group reacts selectively with thiol groups (-SH) in cysteine residues of proteins, enabling the attachment of biomolecules. The N-hydroxysuccinimide (NHS) ester moiety allows it to react with primary amines (-NH2) present in lysine residues or other amine-containing molecules, facilitating crosslinking or labeling. It is particularly useful in antibody-drug conjugates (ADCs), where it links antibodies to cytotoxic drugs, enhancing targeted cancer therapy. Additionally, it is employed in the preparation of biosensors, immobilization of enzymes, and the study of protein interactions. Its bifunctional nature makes it a versatile tool in biochemical research and therapeutic development.
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