AG-490 (Tyrphostin B42)

≥98%

  • Product Code: 77441
  CAS:    133550-30-8
Molecular Weight: 294.30 g./mol Molecular Formula: C₁₇H₁₄N₂O₃
EC Number: MDL Number: MFCD00236452
Melting Point: 215°C Boiling Point:
Density: Storage Condition: -20°C
Product Description: AG-490, also known as Tyrphostin B42, is primarily used in research settings as a selective inhibitor of the JAK2 tyrosine kinase. It is widely employed in studies focused on understanding cellular signaling pathways, particularly those involving the JAK-STAT pathway, which plays a critical role in immune response, cell growth, and differentiation. Researchers use AG-490 to investigate its potential in suppressing abnormal cell proliferation, making it a valuable tool in cancer research, especially for hematologic malignancies like leukemia and lymphoma. Additionally, it is utilized in studies exploring inflammatory diseases and autoimmune disorders, where JAK2 signaling is implicated. Its ability to modulate these pathways provides insights into therapeutic strategies targeting specific kinase activities.
Product Specification:
Test Specification
APPEARANCE yellow powder or crystals
PURITY 98-100
Infrared spectrum Conforms to Structure
Sizes / Availability / Pricing:
Size (g) Availability Price Quantity
0.050 10-20 days ฿3,860.00
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-
0.250 10-20 days ฿15,990.00
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-
AG-490 (Tyrphostin B42)
AG-490, also known as Tyrphostin B42, is primarily used in research settings as a selective inhibitor of the JAK2 tyrosine kinase. It is widely employed in studies focused on understanding cellular signaling pathways, particularly those involving the JAK-STAT pathway, which plays a critical role in immune response, cell growth, and differentiation. Researchers use AG-490 to investigate its potential in suppressing abnormal cell proliferation, making it a valuable tool in cancer research, especially for hematologic malignancies like leukemia and lymphoma. Additionally, it is utilized in studies exploring inflammatory diseases and autoimmune disorders, where JAK2 signaling is implicated. Its ability to modulate these pathways provides insights into therapeutic strategies targeting specific kinase activities.
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