5'-DMT-3'-TBDMS-Bz-rA
95%
- Product Code: 97187
CAS:
81256-88-4
| Molecular Weight: | 787.98 g./mol | Molecular Formula: | C₄₄H₄₉N₅O₇Si |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00274103 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | room temperature, dry |
Product Description:
This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of nucleic acid research. It serves as a protected nucleoside intermediate, enabling the controlled construction of RNA sequences. The 5'-DMT (dimethoxytrityl) group protects the 5'-hydroxyl during synthesis, while the 3'-TBDMS (tert-butyldimethylsilyl) group safeguards the 3'-hydroxyl. The Bz (benzoyl) group protects the exocyclic amine. This protection strategy is crucial in solid-phase synthesis, allowing for the stepwise addition of nucleotides to build specific RNA strands. It is widely applied in the development of therapeutic oligonucleotides, such as antisense RNAs and siRNAs, which are used in gene silencing and targeted therapies. Additionally, it plays a role in the study of RNA structure, function, and interactions, contributing to advancements in molecular biology and drug discovery.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.025 | 10-20 days | ฿756.00 |
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| 0.100 | 10-20 days | ฿1,782.00 |
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| 0.250 | 10-20 days | ฿3,564.00 |
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| 1.000 | 10-20 days | ฿9,234.00 |
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5'-DMT-3'-TBDMS-Bz-rA
This chemical is primarily used in the synthesis of oligonucleotides, particularly in the field of nucleic acid research. It serves as a protected nucleoside intermediate, enabling the controlled construction of RNA sequences. The 5'-DMT (dimethoxytrityl) group protects the 5'-hydroxyl during synthesis, while the 3'-TBDMS (tert-butyldimethylsilyl) group safeguards the 3'-hydroxyl. The Bz (benzoyl) group protects the exocyclic amine. This protection strategy is crucial in solid-phase synthesis, allowing for the stepwise addition of nucleotides to build specific RNA strands. It is widely applied in the development of therapeutic oligonucleotides, such as antisense RNAs and siRNAs, which are used in gene silencing and targeted therapies. Additionally, it plays a role in the study of RNA structure, function, and interactions, contributing to advancements in molecular biology and drug discovery.
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