O-6-Benzylguanine
98%
- Product Code: 98065
Alias:
O-6-Benzylguanine; 2-Amino-6-(Benzyloxy)purine
CAS:
19916-73-5
| Molecular Weight: | 241.25 g./mol | Molecular Formula: | C₁₂H₁₁N₅O |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00269931 | |
| Melting Point: | 193(dec.) | Boiling Point: | |
| Density: | Storage Condition: | Room temperature, dry, sealed |
Product Description:
O-6-Benzylguanine is primarily used in biomedical research as a potent inhibitor of the DNA repair protein O-6-alkylguanine-DNA alkyltransferase (AGT). This protein plays a crucial role in repairing DNA damage caused by alkylating agents, which are often used in chemotherapy. By inhibiting AGT, O-6-Benzylguanine enhances the effectiveness of alkylating chemotherapeutic drugs, making it a valuable tool in cancer treatment strategies. It is particularly useful in sensitizing tumor cells to therapies that involve alkylating agents, thereby improving therapeutic outcomes. Additionally, it is employed in laboratory studies to investigate DNA repair mechanisms and to develop targeted cancer therapies.
Product Specification:
| Test | Specification |
|---|---|
| Melting point | 191 193? |
| PURITYHPLC | 98 100% |
| APPEARANCE | White crystals |
| INFRARED SPECTRUM | Conforms to Structure |
| SOLUBILITY IN WATER | CLEAR21 MG/ML IN METHANOL WITH HEAT |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.100 | 10-20 days | ฿260.00 |
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| 0.500 | 10-20 days | ฿290.00 |
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| 1.000 | 10-20 days | ฿320.00 |
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| 5.000 | 10-20 days | ฿390.00 |
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| 25.000 | 10-20 days | ฿1,360.00 |
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| 100.000 | 10-20 days | ฿5,360.00 |
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O-6-Benzylguanine
O-6-Benzylguanine is primarily used in biomedical research as a potent inhibitor of the DNA repair protein O-6-alkylguanine-DNA alkyltransferase (AGT). This protein plays a crucial role in repairing DNA damage caused by alkylating agents, which are often used in chemotherapy. By inhibiting AGT, O-6-Benzylguanine enhances the effectiveness of alkylating chemotherapeutic drugs, making it a valuable tool in cancer treatment strategies. It is particularly useful in sensitizing tumor cells to therapies that involve alkylating agents, thereby improving therapeutic outcomes. Additionally, it is employed in laboratory studies to investigate DNA repair mechanisms and to develop targeted cancer therapies.
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