Purine Nucleoside Phosphorylase
≥200U/mg protein
- Product Code: 98901
CAS:
9030-21-1
| Molecular Weight: | 32 kDa (SDS-PAGE) g./mol | Molecular Formula: | |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20ºC |
Product Description:
Purine Nucleoside Phosphorylase plays a crucial role in the biochemical pathways of nucleotide metabolism, specifically in the salvage pathway. It catalyzes the reversible phosphorolysis of nucleosides, such as inosine and guanosine, to their respective bases and ribose-1-phosphate. This enzyme is essential for maintaining the balance of purine nucleotides within cells, which is vital for DNA and RNA synthesis.
In medical applications, Purine Nucleoside Phosphorylase is a target for therapeutic interventions. Inhibitors of this enzyme are being explored for their potential in treating certain types of cancers and autoimmune diseases. By inhibiting the enzyme, it is possible to disrupt the proliferation of rapidly dividing cells, such as cancer cells, which rely heavily on nucleotide synthesis.
Additionally, deficiencies in Purine Nucleoside Phosphorylase activity are linked to severe immunodeficiency disorders. Understanding the enzyme's function and regulation can aid in developing gene therapy approaches to correct these deficiencies, thereby restoring immune function in affected individuals.
In the field of biotechnology, this enzyme is utilized in enzymatic assays and research studies to investigate nucleotide metabolism and its regulatory mechanisms. It also serves as a tool in the synthesis of nucleoside analogs, which are important in the development of antiviral and anticancer drugs.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | white powder |
| Protein | 200Umg |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 | 10-20 days | ฿19,680.00 |
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| 500.000 | 10-20 days | ฿13,800.00 |
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Purine Nucleoside Phosphorylase
Purine Nucleoside Phosphorylase plays a crucial role in the biochemical pathways of nucleotide metabolism, specifically in the salvage pathway. It catalyzes the reversible phosphorolysis of nucleosides, such as inosine and guanosine, to their respective bases and ribose-1-phosphate. This enzyme is essential for maintaining the balance of purine nucleotides within cells, which is vital for DNA and RNA synthesis.
In medical applications, Purine Nucleoside Phosphorylase is a target for therapeutic interventions. Inhibitors of this enzyme are being explored for their potential in treating certain types of cancers and autoimmune diseases. By inhibiting the enzyme, it is possible to disrupt the proliferation of rapidly dividing cells, such as cancer cells, which rely heavily on nucleotide synthesis.
Additionally, deficiencies in Purine Nucleoside Phosphorylase activity are linked to severe immunodeficiency disorders. Understanding the enzyme's function and regulation can aid in developing gene therapy approaches to correct these deficiencies, thereby restoring immune function in affected individuals.
In the field of biotechnology, this enzyme is utilized in enzymatic assays and research studies to investigate nucleotide metabolism and its regulatory mechanisms. It also serves as a tool in the synthesis of nucleoside analogs, which are important in the development of antiviral and anticancer drugs.
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