AT-56
99%
- Product Code: 99568
CAS:
162640-98-4
| Molecular Weight: | 397.52 g./mol | Molecular Formula: | C₂₅H₂₇N₅ |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20℃ |
Product Description:
AT-56 is primarily utilized in research settings for its role as a selective inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT-1). This enzyme plays a crucial role in cholesterol esterification, a process that influences cholesterol absorption and storage within cells. By inhibiting ACAT-1, AT-56 helps researchers study the mechanisms of cholesterol metabolism and its impact on various diseases, particularly atherosclerosis.
In laboratory experiments, AT-56 is often used to investigate the potential therapeutic effects of ACAT-1 inhibition in reducing cholesterol accumulation in macrophages, which is a key factor in the development of atherosclerotic plaques. Additionally, it aids in exploring the relationship between cholesterol metabolism and other conditions, such as neurodegenerative diseases and cancer, where altered cholesterol homeostasis may play a role.
AT-56 is also valuable in drug development studies, serving as a tool compound to evaluate the efficacy and safety of new ACAT inhibitors. Its specificity for ACAT-1 makes it a useful agent for distinguishing the biological functions of ACAT-1 from those of ACAT-2, another isoform of the enzyme. This distinction is critical for understanding the specific pathways involved in cholesterol-related disorders and for designing targeted therapies.
Overall, AT-56 is a significant tool in biochemical and pharmacological research, contributing to advancements in understanding cholesterol metabolism and its implications for human health.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | White to Off-white to Beige Powder or Crystals |
| PURITY | 98.5-100 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | ฿2,910.00 |
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AT-56
AT-56 is primarily utilized in research settings for its role as a selective inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT-1). This enzyme plays a crucial role in cholesterol esterification, a process that influences cholesterol absorption and storage within cells. By inhibiting ACAT-1, AT-56 helps researchers study the mechanisms of cholesterol metabolism and its impact on various diseases, particularly atherosclerosis.
In laboratory experiments, AT-56 is often used to investigate the potential therapeutic effects of ACAT-1 inhibition in reducing cholesterol accumulation in macrophages, which is a key factor in the development of atherosclerotic plaques. Additionally, it aids in exploring the relationship between cholesterol metabolism and other conditions, such as neurodegenerative diseases and cancer, where altered cholesterol homeostasis may play a role.
AT-56 is also valuable in drug development studies, serving as a tool compound to evaluate the efficacy and safety of new ACAT inhibitors. Its specificity for ACAT-1 makes it a useful agent for distinguishing the biological functions of ACAT-1 from those of ACAT-2, another isoform of the enzyme. This distinction is critical for understanding the specific pathways involved in cholesterol-related disorders and for designing targeted therapies.
Overall, AT-56 is a significant tool in biochemical and pharmacological research, contributing to advancements in understanding cholesterol metabolism and its implications for human health.
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