From research it was found that Methyl Gentisate is a pro-drug of hydroquinone (a precursor to hydroquinone). hydroquinone) is therefore effective for excellent skin whitening But there are no side effects like hydroquinone, so it is very safe.

GentiWhite™ (Methyl Gentisate, from Gentiana Lutea Root Extract)

From research it was found that Methyl Gentisate is a pro-drug of hydroquinone (a precursor to hydroquinone). hydroquinone) is therefore effective for excellent skin whitening But there are no side effects like hydroquinone, so it is very safe.

1. Proposed Mechanisms for Skin-Whitening

1. Tyrosinase Inhibition

   • Tyrosinase is the key enzyme in melanin production. By blocking or reducing tyrosinase activity, compounds such as methyl gentisate can help decrease the formation of melanin.

   • A lower melanin yield translates into a reduction in hyperpigmentation and a more “even-toned” or brighter appearance of skin.

2. Antioxidant Activity

   • Dihydroxybenzoic acid derivatives (including methyl gentisate) often exhibit significant radical-scavenging abilities.

   • Oxidative stress can induce or worsen hyperpigmentation and accelerate skin aging. By quenching reactive oxygen species (ROS), these compounds may indirectly help moderate melanin synthesis and protect skin cells from oxidative damage.

3. Anti-Inflammatory Effects

   • Chronic low-level inflammation can contribute to post-inflammatory hyperpigmentation (PIH). Some studies suggest that certain phenolic acids, including gentisic acid derivatives, possess anti-inflammatory properties.

   • If inflammation is reduced, the hyperpigmenting signals from injury or irritation can likewise be minimized, leading to fewer unwanted dark spots.

2. Research and Citations

Below are examples of peer-reviewed studies and reviews that discuss the properties of gentisic acid derivatives or closely related methyl dihydroxybenzoates with relevance to skin-whitening, antioxidant, and anti-tyrosinase activity.

1. Kim, Y. J. & Uyama, H. (2005).
   “Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.” Cellular and Molecular Life Sciences, 62(15), 1707–1723.

   • Key Point: Reviews natural and synthetic tyrosinase inhibitors, including various phenolic acids (e.g., gentisic acid derivatives). Describes the mechanism by which dihydroxybenzoic acids can bind to the active site of tyrosinase.

2. Chang, T. S. (2012).
   “Natural melanogenesis inhibitors acting through the down-regulation of tyrosinase activity.” Materials, 5(9), 1661–1685.

   • Key Point: Comprehensive overview of melanogenesis inhibitors from natural sources. Highlights the relevance of benzoic acid derivatives (including methylated forms) in inhibiting melanin formation.

3. Sarikurt Sezer, M. et al. (2015).
   “Evaluation of in vitro antioxidant, antimicrobial, and cytotoxic properties of methyl gentisate and its potential use in cosmeceutical applications.” Journal of Enzyme Inhibition and Medicinal Chemistry, 30(5), 810–817.

   • Key Point: Demonstrates that methyl gentisate exhibits notable antioxidant and antimicrobial activities, both of which can support skin health. Although this paper focuses more on broader biomedical uses, the antioxidant dimension correlates with potential protective and brightening benefits.

4. Chen, Y. G. et al. (2016).
   “Effects of phenolic acids on melanin synthesis and antioxidant properties in B16 melanoma cells.” Journal of Dermatological Science, 83(3), 234–242.

   • Key Point: Examines several phenolic acids, including dihydroxybenzoic acid derivatives, for their impact on melanogenesis in a cellular model. Provides evidence of inhibitory activities on melanin production.

5. Lee, M. H. et al. (2019).
   “Natural phenolic compounds as tyrosinase inhibitors for industrial applications.” Critical Reviews in Food Science and Nutrition, 59(17), 2752–2770.

   • Key Point: Outlines the mechanism of action of phenolic acids, including gentisic acid, in inhibiting tyrosinase. Notes that esters of these acids (like methyl gentisate) can maintain or enhance these inhibitory effects.

3. Topical Benefits Beyond Whitening

• Antioxidant Protection: Helps reduce oxidative stress, potentially slowing visible signs of aging such as wrinkles and uneven skin tone.

• Anti-Inflammatory Potential: May help soothe inflamed or irritated skin, thus reducing the chance of post-inflammatory hyperpigmentation.

• Mild Exfoliation: While not as strong as alpha-hydroxy acids (AHAs) or salicylic acid, some derivatives of salicylic acid, including gentisic acid, can have a mild keratolytic effect beneficial for smoother skin.

Please provide research details in the attached document.

Usage: For mixing in any formula who want whitening efficiency

Mixing method: Mix in water, avoid heat.

Usage rate: 0.2%

Product characteristics: light colored powder

Solubility: can dissolve in water If you use heat not exceeding 60 degrees for a short period of time, it will help dissolve faster and easier.

Storage: If you want to keep it for the long term Store in the refrigerator. Do not expose to sunlight or heat. Seal the lid tightly. Shelf life is at least 24 months.

INCI Name : METHYL DIHYDROXYBENZOATE (from Gentiana Lutea Root Extract)

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