Calcium Bisglycinate (Monohydrate, 19% Calcium)

Calcium Bisglycinate (Monohydrate, 19% Calcium)
Food Code: 8647

Bisglycinate type can be absorbed into the body better than other types used to strengthen calcium minerals. to the body which is a mineral necessary for bone formation

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Calcium Bisglycinate

Bisglycinate type can be absorbed into the body better than other types.

Used to strengthen calcium to the body which is a mineral necessary for bone formation

Calcium bis-glycinate monohydrate (≈19 % elemental Ca) is an amino-acid chelate in which each Ca²⁺ ion is wrapped by two glycinate ligands and one crystal-water molecule. Because the Ca–N/O bonds stay intact through the stomach and break in the small intestine, the mineral enters the absorptive pathway as a small neutral complex instead of an insoluble salt. That difference drives most of the health advantages listed below.

1. Superior absorption and retention

Finding Key data Why it matters
Higher fractional absorption (≈40–45 %) In Heaney’s isotopic crossover trial, Ca bis-glycinate (CaBG) delivered the largest area-under-curve and Cmax compared with carbonate, citrate and micro-crystalline hydroxy-apatite (MCHC). pubmed.ncbi.nlm.nih.gov More milligrams actually enter the blood, so lower doses can meet daily targets.
Resistance to dietary inhibitors A 2024 review noted that CaBG “has the highest solubility among common Ca salts” and is 1.5–2× better absorbed than carbonate/citrate even in high-oxalate or phytate meals. nutritionaloutlook.com Helpful for vegan or spinach-rich diets, bariatric patients, and anyone with sub-optimal gastric acid.
Acid-independent uptake Chelated Ca requires no gastric acid; bioaccessibility in whey drinks remained high across pH 2–7, whereas tricalcium phosphate fell sharply. sciencedirect.com Makes CaBG reliable for older adults, people taking PPIs/H₂-blockers, or with achlorhydria.


2. Bone & skeletal benefits

  • Peak-bone-mass support (≤35 y). A 2022 meta-analysis of 43 RCTs showed calcium supplementation significantly increased total and femoral-neck BMD in adults under 35 y, with larger gains when daily elemental Ca ≥ 800 mg. pubmed.ncbi.nlm.nih.gov Because CaBG is more absorbable per milligram, smaller tablets/capsules can still deliver these intakes.
  • Post-menopausal bone maintenance. Trials that combined CaBG (500–1 000 mg Ca/day) with vitamin D lowered bone-turnover markers and slowed spine BMD loss versus Ca carbonate at equal doses. alternative-therapies.com
  • Collagen matrix support. Each gram of CaBG supplies ≈ 360 mg glycine—a conditionally essential substrate for the type-I collagen scaffold in bone. High glycine availability up-regulates collagen synthesis in chondrocytes and osteoblasts. pmc.ncbi.nlm.nih.gov


3. Gentler gastrointestinal profile

Symptom Ca carbonate Ca bis-glycinate
Constipation / bloating Common—carbonate reacts with gastric acid, forms CO₂ and harder stools. health.harvard.edu Rare—chelates are neutral and leave no insoluble residue. Product surveys and marketing data consistently position CaBG as “stomach-gentle.” atamanchemicals.com carlsonlabs.com

In practice this means better long-term adherence, especially in pregnancy or elder care where GI tolerance dictates compliance.


4. Additional use-case advantages

  • Lower pill burden: 19 % Ca means ~ 1.3 g CaBG delivers the same elemental Ca as 600 mg of carbonate (1.5 g).
  • Fewer kidney-stone concerns: By avoiding large transient spikes of free Ca²⁺ in the gut lumen, chelates are theorised to reduce oxalate complexation; observational safety reviews show no excess stone risk. nutritionaloutlook.com
  • Compatible with beverages & effervescents: High aqueous solubility lets formulators make clear RTD drinks or powders without gritty sediment. nutritionaloutlook.com


5. Regulatory & safety status

  • EU: EFSA approved Ca bis-glycinate as a permitted mineral source for foods and supplements in 2008 after a full safety dossier. efsa.onlinelibrary.wiley.com
  • USA/Canada/JP: Listed as GRAS (self-affirmed) or accepted under the broader “amino-acid mineral chelate” category; no specific maximum level beyond standard calcium UL (2 500 mg/day for adults).
  • Tolerability: Clinical studies up to 1 000 mg elemental Ca/day for 6–12 months report no serious adverse events; mild GI complaints under 3 %. alternative-therapies.com


6. Practical dosing guide

Life stage RDA / AI (elemental Ca) CaBG needed
9–18 y 1 300 mg 6.8 g
19–50 y 1 000 mg 5.3 g
Women > 50 y & Men > 70 y 1 200 mg 6.3 g
Pregnancy/Lactation 1 000 mg 5.3 g

Tip: split doses ≤ 500 mg elemental Ca (≈ 2.6 g CaBG) for best fractional absorption. Co-administer vitamin D₃ (600–1 000 IU) and vitamin K₂-MK-7 (90–120 µg) to optimise bone deposition.


Key take-aways for formulators & clinicians

  1. Bioavailability first. Better uptake and inhibitor resistance allow lower gram weights and smaller tablets—even critical in elderly or paediatric groups.
  2. Tolerability drives adherence. The low-acid, low-carbonation profile leads to higher day-to-day compliance.
  3. Dual-nutrient synergy. The co-delivered glycine may subtly improve collagen-matrix quality, adding value beyond mere Ca supply.

Overall, calcium bis-glycinate monohydrate is a well-tolerated, highly absorbable option that effectively supports bone health and overcomes several limitations of traditional calcium salts. Always individualise dosing and monitor total dietary + supplemental calcium to stay below the tolerable-upper-intake level.


  • Room (25-40C)
  • 24 Months from manufacturing or testing date.
  • 250mg - 1000mg
  • 500mg
  • 250mg - 1000mg
  • 500mg
  • Add into water phase. Heat tolerant.
  • Avoid heat above 60C
  • 3.50 - 7.00
  • Soluble in Water, Dispersible in water, Soluble in DMSO (Dimethyl Sulfoxide)
  • -
Test Name Specification
Appearance White crystalline powder
Calcium (on dried basis), w/% ≥19.0%
Loss on drying, w/% ≤9.0%
pH (10g/L) 10.0-12.0
Particle size, w/% 90% passing 60 mesh
Lead (Pb) ≤3 ppm
Arsenic (As) ≤1 ppm
Cadmium (Cd) ≤1 ppm
Mercury (Hg) ≤0.1 ppm
Total plate count ≤1000 cfu/g
Yeast and Mold ≤100 cfu/g
E. Coli Negative
Salmonella Negative


Calcium Bisglycinate (Monohydrate, 19% Calcium)

Bisglycinate type can be absorbed into the body better than other types used to strengthen calcium minerals. to the body which is a mineral necessary for bone formation

Calcium Bisglycinate

Bisglycinate type can be absorbed into the body better than other types.

Used to strengthen calcium to the body which is a mineral necessary for bone formation

Calcium bis-glycinate monohydrate (≈19 % elemental Ca) is an amino-acid chelate in which each Ca²⁺ ion is wrapped by two glycinate ligands and one crystal-water molecule. Because the Ca–N/O bonds stay intact through the stomach and break in the small intestine, the mineral enters the absorptive pathway as a small neutral complex instead of an insoluble salt. That difference drives most of the health advantages listed below.

1. Superior absorption and retention

Finding Key data Why it matters
Higher fractional absorption (≈40–45 %) In Heaney’s isotopic crossover trial, Ca bis-glycinate (CaBG) delivered the largest area-under-curve and Cmax compared with carbonate, citrate and micro-crystalline hydroxy-apatite (MCHC). pubmed.ncbi.nlm.nih.gov More milligrams actually enter the blood, so lower doses can meet daily targets.
Resistance to dietary inhibitors A 2024 review noted that CaBG “has the highest solubility among common Ca salts” and is 1.5–2× better absorbed than carbonate/citrate even in high-oxalate or phytate meals. nutritionaloutlook.com Helpful for vegan or spinach-rich diets, bariatric patients, and anyone with sub-optimal gastric acid.
Acid-independent uptake Chelated Ca requires no gastric acid; bioaccessibility in whey drinks remained high across pH 2–7, whereas tricalcium phosphate fell sharply. sciencedirect.com Makes CaBG reliable for older adults, people taking PPIs/H₂-blockers, or with achlorhydria.


2. Bone & skeletal benefits

  • Peak-bone-mass support (≤35 y). A 2022 meta-analysis of 43 RCTs showed calcium supplementation significantly increased total and femoral-neck BMD in adults under 35 y, with larger gains when daily elemental Ca ≥ 800 mg. pubmed.ncbi.nlm.nih.gov Because CaBG is more absorbable per milligram, smaller tablets/capsules can still deliver these intakes.
  • Post-menopausal bone maintenance. Trials that combined CaBG (500–1 000 mg Ca/day) with vitamin D lowered bone-turnover markers and slowed spine BMD loss versus Ca carbonate at equal doses. alternative-therapies.com
  • Collagen matrix support. Each gram of CaBG supplies ≈ 360 mg glycine—a conditionally essential substrate for the type-I collagen scaffold in bone. High glycine availability up-regulates collagen synthesis in chondrocytes and osteoblasts. pmc.ncbi.nlm.nih.gov


3. Gentler gastrointestinal profile

Symptom Ca carbonate Ca bis-glycinate
Constipation / bloating Common—carbonate reacts with gastric acid, forms CO₂ and harder stools. health.harvard.edu Rare—chelates are neutral and leave no insoluble residue. Product surveys and marketing data consistently position CaBG as “stomach-gentle.” atamanchemicals.com carlsonlabs.com

In practice this means better long-term adherence, especially in pregnancy or elder care where GI tolerance dictates compliance.


4. Additional use-case advantages

  • Lower pill burden: 19 % Ca means ~ 1.3 g CaBG delivers the same elemental Ca as 600 mg of carbonate (1.5 g).
  • Fewer kidney-stone concerns: By avoiding large transient spikes of free Ca²⁺ in the gut lumen, chelates are theorised to reduce oxalate complexation; observational safety reviews show no excess stone risk. nutritionaloutlook.com
  • Compatible with beverages & effervescents: High aqueous solubility lets formulators make clear RTD drinks or powders without gritty sediment. nutritionaloutlook.com


5. Regulatory & safety status

  • EU: EFSA approved Ca bis-glycinate as a permitted mineral source for foods and supplements in 2008 after a full safety dossier. efsa.onlinelibrary.wiley.com
  • USA/Canada/JP: Listed as GRAS (self-affirmed) or accepted under the broader “amino-acid mineral chelate” category; no specific maximum level beyond standard calcium UL (2 500 mg/day for adults).
  • Tolerability: Clinical studies up to 1 000 mg elemental Ca/day for 6–12 months report no serious adverse events; mild GI complaints under 3 %. alternative-therapies.com


6. Practical dosing guide

Life stage RDA / AI (elemental Ca) CaBG needed
9–18 y 1 300 mg 6.8 g
19–50 y 1 000 mg 5.3 g
Women > 50 y & Men > 70 y 1 200 mg 6.3 g
Pregnancy/Lactation 1 000 mg 5.3 g

Tip: split doses ≤ 500 mg elemental Ca (≈ 2.6 g CaBG) for best fractional absorption. Co-administer vitamin D₃ (600–1 000 IU) and vitamin K₂-MK-7 (90–120 µg) to optimise bone deposition.


Key take-aways for formulators & clinicians

  1. Bioavailability first. Better uptake and inhibitor resistance allow lower gram weights and smaller tablets—even critical in elderly or paediatric groups.
  2. Tolerability drives adherence. The low-acid, low-carbonation profile leads to higher day-to-day compliance.
  3. Dual-nutrient synergy. The co-delivered glycine may subtly improve collagen-matrix quality, adding value beyond mere Ca supply.

Overall, calcium bis-glycinate monohydrate is a well-tolerated, highly absorbable option that effectively supports bone health and overcomes several limitations of traditional calcium salts. Always individualise dosing and monitor total dietary + supplemental calcium to stay below the tolerable-upper-intake level.

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