Determination of Carbamide Peroxide Content by Iodometric Titration Method
Iodometric titration method determines the carbamide peroxide (CP) content in a sample (crystals or gel) by generating iodine in an acidic medium containing potassium iodide and a catalyst (ammonium molybdate). The liberated iodine is titrated with sodium thiosulfate, and the CP content is calculated from the volume of titrant used. Carbamide peroxide is widely used in dental, cosmetic, and pharmaceutical formulations as a bleaching and antiseptic agent. Accurate quantification ensures product efficacy, safety, and regulatory compliance. Under acidic conditions, carbamide peroxide oxidizes iodide to iodine. The amount of iodine generated is stoichiometrically proportional to the CP in the sample. Titration of iodine with standardized sodium thiosulfate provides a reliable measure of CP con