L-Carnosine เป็น Amino Acids ที่มีผลการวิจัยยืนยันว่ามีประโยชน์ต่อผิวหลากหลายด้านดังนี้

1. ป้องกันการเกิด Glycation - Glycation inhibitor and repair [1] [9]

2. ป้องกันแสง UV ทำลายผิว - Sun damage protection [3] [4]

3. ช่วยสมานแผล - Wound healing support [11] [12]

4. ให้ความชุ่มชื้นผิว - Moisturizing & hydration [13] [14]

5. ต่อต้านอนุมูลอิสระ - Antioxidant [4] [5] [6]

6. ฟื้นฟูเกราะป้องกันผิว - Restore skin barrier function [8]

[1]          A. A. Boldyrev, S. C. Gallant, and G. T. Sukhich, “Carnosine, the protective, anti-aging peptide,” Biosci. Rep., vol. 19, no. 6, pp. 581–587, Dec. 1999.
[2]          C. Renner, N. Zemitzsch, B. Fuchs, K. D. Geiger, M. Hermes, J. Hengstler, R. Gebhardt, J. Meixensberger, and F. Gaunitz, “Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model,” Mol. Cancer, vol. 9, p. 2, 2010.
[3]          E. Emanuele, J. M. Spencer, and M. Braun, “An experimental double-blind irradiation study of a novel topical product (TPF 50) compared to other topical products with DNA repair enzymes, antioxidants, and growth factors with sunscreens: implications for preventing skin aging and cancer,” J. Drugs Dermatol. JDD, vol. 13, no. 3, pp. 309–314, Mar. 2014.
[4]          E. Emanuele, M. Bertona, F. Sanchis-Gomar, H. Pareja-Galeano, and A. Lucia, “Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes,” Biomed. Rep., vol. 2, no. 5, pp. 755–759, Sep. 2014.
[5]          M. Y. Kim, E. J. Kim, Y.-N. Kim, C. Choi, and B.-H. Lee, “Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats,” Nutr. Res. Pract., vol. 5, no. 5, pp. 421–428, Oct. 2011.[6]          M. A. Babizhayev, “Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products,” Life Sci., vol. 78, no. 20, pp. 2343–2357, Apr. 2006.
[7]          M. A. Babizhayev, A. I. Deyev, E. L. Savel’yeva, V. Z. Lankin, and Y. E. Yegorov, “Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging,” J. Dermatol. Treat., vol. 23, no. 5, pp. 345–384, Oct. 2012.
[8]          G. de C. Dieamant, M. D. C. Velazquez Pereda, S. Eberlin, C. Nogueira, R. M. Werka, and M. L. de S. Queiroz, “Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment,” J. Cosmet. Dermatol., vol. 7, no. 2, pp. 112–119, Jun. 2008.
[9]          V. P. Reddy, M. R. Garrett, G. Perry, and M. A. Smith, “Carnosine: a versatile antioxidant and antiglycating agent,” Sci. Aging Knowl. Environ. SAGE KE, vol. 2005, no. 18, p. pe12, May 2005
[10]        C. Rona, F. Vailati, and E. Berardesca, “The cosmetic treatment of wrinkles,” J. Cosmet. Dermatol., vol. 3, no. 1, pp. 26–34, Jan. 2004.
[11]        Q. Wessels, E. Pretorius, C. M. Smith, and H. Nel, “The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro,” Int. Wound J., vol. 11, no. 2, pp. 152–158, Apr. 2014.
[12]        I. Ansurudeen, V. G. Sunkari, J. Grünler, V. Peters, C. P. Schmitt, S.-B. Catrina, K. Brismar, and E. A. Forsberg, “Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes,” Amino Acids, vol. 43, no. 1, pp. 127–134, Jul. 2012.
[13]        A. Federici, G. Federici, and M. Milani, “An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial,” BMC Dermatol., vol. 12, p. 16, 2012.
[14]        G. Ciammaichella, G. Belcaro, M. Dugall, M. Hosoi, R. Luzzi, E. Ippolito, and M. R. Cesarone, “Product evaluation of Ureadin Rx Db (ISDIN) for prevention and treatment of mild-to-moderate xerosis of the foot in diabetic patients. Prevention of skin lesions due to microangiopathy,” Panminerva Med., vol. 54, no. 1 Suppl 4, pp. 35–42, Dec. 2012.

การใช้: สำหรับผลิตภัณฑ์ลดริ้วรอย

วิธีการผสม: ผสมในส่วนของน้ำ หลีกเลี่ยงความร้อนเกิน 40องศา สูตรควรมี pH ในช่วง 3.5-7.0

*สูตรควรมีการใช้ Butylene Glycol หรือ Ethoxydiglycol หรือ Laurocapram ในอัตรา 3% เพื่อช่วยนำพา L-Carnosine ให้ซึมเข้าสู่ผิวได้ดีขึ้น*

อัตราการใช้: 0.1-1.0%

ลักษณะผลิตภัณฑ์: ผงสีขาว ไม่สามารถทนความร้อนเกิน 40องศา

การละลาย: ละลายในน้ำ

INCI Name: L-Carnosine

ตัวอย่างผลิตภัณฑ์ที่ใช้ L-Carnosine

LA ROCHE-POSAY Tolerance Ultra Overnight

Paula's Choice Resist Anti-Aging 10% Niacinamide Booster

STRIVECTIN Active Infusion Youth Serum

Elizabeth Arden Prevage Foundation

Nu Skin ageLOC me serum T1