Used to measure the activity of the mouse alpha-ketoglutarate dehydrogenase complex (α-KGDHC) in biological samples such as tissue homogenates, cell lysates, or mitochondrial preparations. This ELISA kit enables researchers to quantify changes in α-KGDHC activity in experimental models of neurological disorders, metabolic diseases, and mitochondrial dysfunction. It is particularly useful in studies related to neurodegeneration, including Alzheimer’s disease research, where impaired α-KGDHC activity is linked to reduced brain energy metabolism. The assay supports high-throughput analysis and provides a reliable, sensitive method for evaluating enzyme function in response to drugs, toxins, or genetic modifications in mouse models.