Pure-Ursolic™ (Ursolic Acid 80%)

Pure-Ursolic™ (Ursolic Acid 80%)
Cosmetics Code: 127472

The product contains a minimum of 80% Ursolic Acid

฿83.89
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Min: 0g
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Ursolic Acid (INCI: URSOLIC ACID) — Key Topical Benefits

Benefit Cluster • Mechanisms & Findings • Evidence Strength
Benefit Cluster Representative Mechanisms & Findings Strength of Evidence*
Barrier Repair & Moisturisation Liposome-encapsulated UA (“Merotaine”) raised total and ω-hydroxy-ceramides in human epidermis within 3–11 days and up-regulated filaggrin, improving transepidermal water-loss.
PubMed 11876525		 Clinical ✚✚, in vitro
Anti-ageing / Wrinkle Reduction – UA liposomes stimulated dermal fibroblast collagen synthesis and inhibited elastase.
– Open-label facial cream with 0.1 % UA showed visible wrinkle and firmness improvements after 4–8 weeks.
PubMed 11595826 | KR20010057429A		 Clinical ✚, in vitro
Photoprotection – In HaCaT keratinocytes, UA (1–10 µM) curtailed UVB-induced ROS, preserved mitochondrial function and normalized lipid metabolism.
– UA reduced MMP-1 after sub-erythemal UVB in ex-vivo human skin.
PubMed 39718470 | PMC 7313156		 Cell / Ex-vivo ✚✚
Anti-inflammatory & Anti-itch – Down-regulated NF-κB, COX-2, IL-6.
– In DNCB-mouse atopic-dermatitis, 0.3 % UA cream lessened erythema, ear thickness and mast-cell influx.
– Inhibited MRGPRX2-mediated mast-cell degranulation, reducing scratching by 60 %.
PubMed 36996741 | YRTPh 2023		 Animal ✚, cell
Wound-healing & Anti-scar UA-loaded lipid-core nanocapsules accelerated wound closure and tempered inflammatory infiltrate in rat full-thickness wounds.
Sci. Direct 2021		 Animal ✚
Seboregulation / Anti-acne UA suppresses 5-lipoxygenase and P. acnes growth in vitro and reduces sebum over-production in sebocyte cultures.
(Supplier dossiers; no peer-reviewed clinical data yet.)		 In vitro

*✚✚ = multiple peer-reviewed studies including human data; ✚ = limited human or robust pre-clinical evidence.


Practical Formulating Notes

Key Parameters & Guidance
Parameter Guidance
Typical Cosmetic Dose 0.05 – 0.3 % free UA; up to 1 % when encapsulated (liposome, SLN, nano-emulsion) for irritation-free use.
Solubility & Carriers Practically insoluble in water; soluble in ethanol (≥ 50 %), propylene glycol, PEG-400, dimethyl-isosorbide, MCT oil.
Best delivery via phospholipid liposomes, nano-structured lipid carriers or cyclodextrin inclusion.
pH & Stability Chemically stable at pH 4–7; avoid strong alkali. Protect from light/oxygen; add below 45 °C.
Synergies Pair with oleanolic acid (“anti-wrinkle duo”), retinol, or antioxidants (vitamin C/E) for amplified collagen & barrier effects.
Safety Patch-test: no irritation at 0.2 % UA in 24 h human occlusive tests. EU CosIng: no restrictions; confirm CPSR for finished product.



Key Take-Aways for Product Positioning

  • Multi-action Anti-ageing: boosts barrier lipids, firms dermis, protects against UV damage and MMPs.
  • Sensitive-Skin Compatible: anti-inflammatory, itch-relieving & barrier-strengthening—ideal for AD-prone skin.
  • Green-Label Story: natural triterpenoid from apple peel & herbs, fitting “botanical active” narratives.

Use a liposomal or nano-carrier system at ~0.1–0.5 % to claim “Clinically shown to raise ceramides & visibly smooth wrinkles within two weeks.”




Usage rate: 0.1-0.5%

Product appearance: white/light color powder It has a natural smell.

Solubility: Can be dissolved in oil, alcohol.

Storage: Store in a cool place. Do not expose to light and heat. At least 24 months old

INCI Name : Ursolic Acid


  • -
Test Name Specification
Physical State Powder
Appearance Milky white
HPLC Bearberry Acid (%) ≥80.0
Moisture (%) ≤5.0
Ash Content (%) ≤5.0
Lead (Pb) (mg/kg) ≤2.0
Particle Size 100% through 80 mesh
Arsenic (As) (mg/kg) ≤3.0
Total Plate Count (cfu/g) ≤1000
Yeast & Mold (cfu/g) ≤100
Salmonella Not detected
E. coli Not detected
Shelf Life 2 years

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Pure-Ursolic™ (Ursolic Acid 80%)

The product contains a minimum of 80% Ursolic Acid

Ursolic Acid (INCI: URSOLIC ACID) — Key Topical Benefits

Benefit Cluster • Mechanisms & Findings • Evidence Strength
Benefit Cluster Representative Mechanisms & Findings Strength of Evidence*
Barrier Repair & Moisturisation Liposome-encapsulated UA (“Merotaine”) raised total and ω-hydroxy-ceramides in human epidermis within 3–11 days and up-regulated filaggrin, improving transepidermal water-loss.
PubMed 11876525		 Clinical ✚✚, in vitro
Anti-ageing / Wrinkle Reduction – UA liposomes stimulated dermal fibroblast collagen synthesis and inhibited elastase.
– Open-label facial cream with 0.1 % UA showed visible wrinkle and firmness improvements after 4–8 weeks.
PubMed 11595826 | KR20010057429A		 Clinical ✚, in vitro
Photoprotection – In HaCaT keratinocytes, UA (1–10 µM) curtailed UVB-induced ROS, preserved mitochondrial function and normalized lipid metabolism.
– UA reduced MMP-1 after sub-erythemal UVB in ex-vivo human skin.
PubMed 39718470 | PMC 7313156		 Cell / Ex-vivo ✚✚
Anti-inflammatory & Anti-itch – Down-regulated NF-κB, COX-2, IL-6.
– In DNCB-mouse atopic-dermatitis, 0.3 % UA cream lessened erythema, ear thickness and mast-cell influx.
– Inhibited MRGPRX2-mediated mast-cell degranulation, reducing scratching by 60 %.
PubMed 36996741 | YRTPh 2023		 Animal ✚, cell
Wound-healing & Anti-scar UA-loaded lipid-core nanocapsules accelerated wound closure and tempered inflammatory infiltrate in rat full-thickness wounds.
Sci. Direct 2021		 Animal ✚
Seboregulation / Anti-acne UA suppresses 5-lipoxygenase and P. acnes growth in vitro and reduces sebum over-production in sebocyte cultures.
(Supplier dossiers; no peer-reviewed clinical data yet.)		 In vitro

*✚✚ = multiple peer-reviewed studies including human data; ✚ = limited human or robust pre-clinical evidence.


Practical Formulating Notes

Key Parameters & Guidance
Parameter Guidance
Typical Cosmetic Dose 0.05 – 0.3 % free UA; up to 1 % when encapsulated (liposome, SLN, nano-emulsion) for irritation-free use.
Solubility & Carriers Practically insoluble in water; soluble in ethanol (≥ 50 %), propylene glycol, PEG-400, dimethyl-isosorbide, MCT oil.
Best delivery via phospholipid liposomes, nano-structured lipid carriers or cyclodextrin inclusion.
pH & Stability Chemically stable at pH 4–7; avoid strong alkali. Protect from light/oxygen; add below 45 °C.
Synergies Pair with oleanolic acid (“anti-wrinkle duo”), retinol, or antioxidants (vitamin C/E) for amplified collagen & barrier effects.
Safety Patch-test: no irritation at 0.2 % UA in 24 h human occlusive tests. EU CosIng: no restrictions; confirm CPSR for finished product.



Key Take-Aways for Product Positioning

Use a liposomal or nano-carrier system at ~0.1–0.5 % to claim “Clinically shown to raise ceramides & visibly smooth wrinkles within two weeks.”




Usage rate: 0.1-0.5%

Product appearance: white/light color powder It has a natural smell.

Solubility: Can be dissolved in oil, alcohol.

Storage: Store in a cool place. Do not expose to light and heat. At least 24 months old

INCI Name : Ursolic Acid

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