CP-640186 hydrochloride is primarily utilized in research settings to study its effects on metabolic processes, particularly in the context of glucose metabolism and insulin sensitivity. It functions as a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme involved in the regulation of cortisol levels within tissues. By inhibiting this enzyme, it helps researchers explore potential therapeutic strategies for metabolic disorders such as type 2 diabetes and obesity. Additionally, it is used in preclinical studies to investigate its role in reducing glucocorticoid-induced insulin resistance and improving lipid profiles. Its application extends to understanding the interplay between cortisol metabolism and metabolic syndrome, providing insights into novel treatment approaches.