LolCDE-IN-1 is primarily utilized in the field of antibacterial research and development. It functions as an inhibitor targeting the LolCDE complex, which plays a crucial role in the lipoprotein transport system of Gram-negative bacteria. By disrupting this system, it effectively hinders the bacteria's ability to transport essential lipoproteins to their outer membrane, leading to impaired bacterial growth and survival. This makes it a promising candidate for the development of novel antibiotics, particularly in addressing infections caused by multidrug-resistant Gram-negative pathogens. Its application is significant in advancing therapeutic strategies against bacterial infections that are increasingly difficult to treat with existing antibiotics.