Ko143 hydrate

98%

Reagent Code: #110831
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Alias Ko143 hydrate; Ko-143 hydrate
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CAS Number 461054-93-3
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Properties DMSO: >10 mg/mL

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 469.57 g/mol
Formula C₂₆H₃₅N₃O₅
badge Registry Numbers
MDL Number MFCD19053160
thermostat Physical Properties
Melting Point 147 ºC
Boiling Point 689.8±55.0 °C at 760 mmHg
inventory_2 Storage & Handling
Density 1.24 g/ml
Storage -20°C, sealed, dry

description Product Description

Ko143 hydrate is primarily used in research settings as a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). It is extensively applied in studies focused on understanding drug resistance mechanisms in cancer therapy, particularly in overcoming multidrug resistance. Researchers utilize it to investigate the role of BCRP in the efflux of chemotherapeutic agents, which helps in developing strategies to enhance the efficacy of cancer treatments. Additionally, it is employed in pharmacokinetic studies to assess the impact of BCRP on drug absorption, distribution, and excretion. Its application also extends to stem cell research, where it aids in identifying and isolating stem cell populations based on BCRP expression.

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Test Parameter Specification
Purity (HPLC) 98-100
Appearance White To Off-White Powder
Infrared Spectrometry Conforms to Structure
Solubility >10 mg/mL in DMSO

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 1mg
10-20 days ฿2,480.00
inventory 5mg
10-20 days ฿7,590.00
inventory 25mg
10-20 days ฿25,990.00
Ko143 hydrate
Ko143 hydrate is primarily used in research settings as a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). It is extensively applied in studies focused on understanding drug resistance mechanisms in cancer therapy, particularly in overcoming multidrug resistance. Researchers utilize it to investigate the role of BCRP in the efflux of chemotherapeutic agents, which helps in developing strategies to enhance the efficacy of cancer treatments. Additionally, it is employed in pharmacokinetic studies to assess the impact of BCRP on drug absorption, distribution, and excretion. Its application also extends to stem cell research, where it aids in identifying and isolating stem cell populations based on BCRP expression.
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