Ko143 hydrate
98%
Reagent
Code: #110831
Alias
Ko143 hydrate; Ko-143 hydrate
CAS Number
461054-93-3
Properties
DMSO: >10 mg/mL
blur_circular Chemical Specifications
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Molecular Information
Weight
469.57 g/mol
Formula
C₂₆H₃₅N₃O₅
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Registry Numbers
MDL Number
MFCD19053160
thermostat
Physical Properties
Melting Point
147 ºC
Boiling Point
689.8±55.0 °C at 760 mmHg
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Storage & Handling
Density
1.24 g/ml
Storage
-20°C, sealed, dry
description Product Description
Ko143 hydrate is primarily used in research settings as a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). It is extensively applied in studies focused on understanding drug resistance mechanisms in cancer therapy, particularly in overcoming multidrug resistance. Researchers utilize it to investigate the role of BCRP in the efflux of chemotherapeutic agents, which helps in developing strategies to enhance the efficacy of cancer treatments. Additionally, it is employed in pharmacokinetic studies to assess the impact of BCRP on drug absorption, distribution, and excretion. Its application also extends to stem cell research, where it aids in identifying and isolating stem cell populations based on BCRP expression.
format_list_bulleted Product Specification
Test Parameter | Specification |
---|---|
Purity (HPLC) | 98-100 |
Appearance | White To Off-White Powder |
Infrared Spectrometry | Conforms to Structure |
Solubility | >10 mg/mL in DMSO |
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Ko143 hydrate
Ko143 hydrate is primarily used in research settings as a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). It is extensively applied in studies focused on understanding drug resistance mechanisms in cancer therapy, particularly in overcoming multidrug resistance. Researchers utilize it to investigate the role of BCRP in the efflux of chemotherapeutic agents, which helps in developing strategies to enhance the efficacy of cancer treatments. Additionally, it is employed in pharmacokinetic studies to assess the impact of BCRP on drug absorption, distribution, and excretion. Its application also extends to stem cell research, where it aids in identifying and isolating stem cell populations based on BCRP expression.
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