Zofenopril calcium is primarily used in the treatment of hypertension (high blood pressure) to help lower blood pressure levels, reducing the risk of strokes, heart attacks, and kidney problems. It works by relaxing blood vessels, allowing blood to flow more smoothly. Additionally, it is employed in managing heart failure and improving survival rates after a heart attack. The drug is often prescribed as part of a comprehensive treatment plan that may include diet, exercise, and other medications. It is typically administered orally and requires regular monitoring by healthcare professionals to ensure optimal dosing and effectiveness.