Remodelin hydrobromide is primarily utilized in research focused on cellular aging and nuclear architecture. It functions as an inhibitor of NAT10, an enzyme involved in the acetylation of microtubules, which plays a role in maintaining nuclear structure. By inhibiting NAT10, Remodelin hydrobromide helps restore nuclear morphology in cells with lamin A/C mutations, which are associated with premature aging disorders like Hutchinson-Gilford Progeria Syndrome (HGPS). This makes it a valuable tool in studying cellular mechanisms related to aging and potential therapeutic strategies for progeria and similar conditions. Additionally, it is used in investigations exploring the broader implications of nuclear envelope integrity and its impact on cellular function and longevity.