Used primarily as a versatile reagent in chemical synthesis, especially in the development of pharmaceuticals and agrochemicals. Its sulfonyl fluoride group reacts selectively with nucleophiles, making it valuable for constructing sulfonamide linkages, which are common in bioactive molecules. It serves as a building block in the preparation of proteolysis-targeting chimeras (PROTACs) and other targeted protein degraders due to its ability to act as an electrophilic warhead. Additionally, it is employed in SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry, a robust method for rapid and reliable bond formation in drug discovery and materials science. Its halogen substituents allow for further functionalization via cross-coupling reactions, enhancing its utility in complex molecule assembly.