Widely used in organic synthesis as a powerful reagent for introducing the trifluoroacetyl group. It is particularly effective in peptide synthesis, where it helps activate carboxylic acids and facilitates coupling reactions. Commonly employed in the preparation of trifluoroacetyl-protected amines, which act as intermediates in pharmaceutical manufacturing. Also used in the synthesis of agrochemicals and dyes due to its ability to promote acylation under mild conditions. Frequently applied in analytical chemistry for derivatizing polar compounds, improving their volatility and detectability in gas chromatography and mass spectrometry. Its strong electrophilic nature makes it useful in catalyzing various condensation and dehydration reactions.