Benzyl 1H-benzo[d][1,2,3]triazole-1-carboxylate
95%
blur_circular Chemical Specifications
description Product Description
Benzyl 1H-benzo[d][1,2,3]triazole-1-carboxylate is a specialized reagent in organic synthesis, primarily used for the protection of amines with the carbobenzyloxy (Cbz or Z) group. In peptide synthesis, it enables the selective N-protection of amino acids and peptides under mild conditions, minimizing side reactions and improving yield compared to traditional chlorides like Cbz-Cl. The benzotriazol-1-yl moiety acts as an efficient leaving group, promoting smooth reaction with nucleophilic amines to form stable carbamate protecting groups that are orthogonal to many other protections. Additionally, it is utilized in the preparation of carbamates, ureas, and other nitrogen-containing heterocycles, with applications in medicinal chemistry and pharmaceutical intermediate synthesis due to its stability, solubility, and compatibility with diverse functional groups.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | white solid |
| Purity (%) | 94.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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