Midodrine hydrochloride is primarily used in the management of orthostatic hypotension, a condition where blood pressure drops significantly when a person stands up, leading to dizziness or fainting. It works by constricting blood vessels, which helps to increase blood pressure and improve blood flow to the brain. This medication is particularly beneficial for patients who experience symptoms due to low blood pressure caused by nervous system disorders, prolonged bed rest, or certain medications. It is often prescribed when lifestyle changes and other treatments are insufficient to control the condition. Patients typically take it during the day when they are upright and active, avoiding its use close to bedtime to prevent supine hypertension. Regular monitoring of blood pressure is essential to ensure safe and effective use.