Midodrine is primarily used to treat low blood pressure, particularly orthostatic hypotension, a condition where blood pressure drops significantly when standing up from a sitting or lying position. It works by constricting blood vessels, which helps increase blood pressure and improve symptoms like dizziness, lightheadedness, and fainting. This medication is often prescribed for individuals who experience these symptoms due to conditions such as Parkinson's disease, diabetes, or other autonomic nervous system disorders. It is typically taken orally in specific doses throughout the day, as directed by a healthcare provider, to maintain stable blood pressure levels during activities.