CH-223191 is primarily utilized in research settings to study the aryl hydrocarbon receptor (AhR) pathway. It acts as a selective antagonist, effectively inhibiting AhR activation, which is crucial for understanding the receptor's role in various biological processes. This chemical is particularly valuable in toxicology studies, where it helps elucidate the mechanisms of dioxin and other environmental pollutants that activate AhR. Additionally, CH-223191 is employed in cancer research to investigate the receptor's involvement in tumor progression and immune responses. Its ability to block AhR signaling also makes it a useful tool in studying inflammation and autoimmune diseases, providing insights into potential therapeutic strategies.