GNF351 is primarily utilized in biomedical research, particularly in the study of cellular signaling pathways. It is known for its role as an inhibitor of the aryl hydrocarbon receptor (AhR), a protein involved in various physiological and toxicological processes. Researchers employ GNF351 to investigate the mechanisms of AhR signaling and its impact on immune responses, inflammation, and cancer development. Its application extends to experimental studies aimed at understanding the therapeutic potential of modulating AhR activity in diseases such as autoimmune disorders and certain types of cancer. Additionally, GNF351 is used in pharmacological assays to screen for compounds that interact with AhR, aiding in the development of novel drug candidates.