Bis-propargyl-PEG13 is widely used in the field of bioconjugation and material science due to its unique properties. Its dual propargyl groups make it highly reactive in click chemistry reactions, particularly in copper-catalyzed azide-alkyne cycloaddition (CuAAC). This allows for efficient and selective attachment of molecules, such as proteins, peptides, or drugs, to PEGylated platforms, enhancing their solubility, stability, and bioavailability. In drug delivery systems, it serves as a linker to create targeted therapeutics with controlled release properties. Additionally, it is utilized in the development of hydrogels and functionalized surfaces for tissue engineering and biosensor applications, where precise molecular assembly is critical. Its PEG13 spacer provides flexibility and biocompatibility, making it suitable for biomedical and pharmaceutical research.