DBCO-NH-Boc is widely used in bioorthogonal chemistry due to its reactive DBCO (dibenzocyclooctyne) group, which enables efficient click chemistry reactions without the need for catalysts. It is particularly valuable in labeling biomolecules, such as proteins, peptides, and nucleic acids, as the DBCO group reacts selectively with azide-functionalized compounds. The Boc (tert-butoxycarbonyl) protecting group ensures stability during synthesis, allowing for controlled deprotection when needed. This compound is instrumental in drug discovery, bioconjugation, and the development of targeted therapeutics, where precise and efficient conjugation is critical. Additionally, it is employed in materials science for surface functionalization and the creation of advanced biomaterials.