Propargyl-PEG10-amine is widely used in bioconjugation and chemical synthesis due to its unique properties. Its propargyl group enables click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it valuable for attaching molecules like peptides, proteins, or drugs to larger structures. The PEG10 spacer provides solubility, stability, and reduced immunogenicity, making it ideal for creating biocompatible conjugates in drug delivery systems. It is also employed in surface modification, functionalizing nanoparticles or biomaterials for targeted applications in diagnostics and therapeutics. Additionally, it serves as a linker in the development of prodrugs and bioprobes, enhancing their efficacy and specificity.