TAT 14TFA is a cell-penetrating peptide (CPP) derived from the HIV-1 Tat protein transduction domain, typically consisting of a 14-amino acid sequence (e.g., YGRKKRRQRRRPPQ). It is widely used in biomedical research to enhance the cellular uptake of various molecules, including drugs, proteins, nucleic acids, and nanoparticles, by facilitating transport across cell membranes. TAT 14TFA is particularly valuable in developing targeted drug delivery systems for treating diseases such as cancer, infectious diseases, and genetic disorders. Its applications also extend to studying intracellular processes, protein-protein interactions, and molecular biology mechanisms. The TFA designation commonly refers to the trifluoroacetic acid salt form, which improves solubility and stability for experimental use. In peptide synthesis, protected variants (e.g., with trifluoroacetyl groups) are employed to enable precise bioconjugation and deprotection under mild conditions.