Apramycin sulfate is primarily used in veterinary medicine as an antibiotic to treat bacterial infections in animals, particularly in livestock such as cattle, pigs, and poultry. It is effective against Gram-negative bacteria, including strains of Escherichia coli and Salmonella, which are common causes of gastrointestinal infections in animals. The compound is often administered through feed or water, ensuring easy delivery to large groups of animals. Its use helps in improving animal health and productivity by controlling and preventing infections that can lead to significant economic losses in farming operations. Additionally, apramycin sulfate is sometimes employed in aquaculture to treat bacterial diseases in fish and other aquatic organisms, contributing to the sustainability of fish farming practices.